A/Prof. Daria Smirnova, MD, PhD, Russia

International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, Samara, Russia

Schizophrenia with predominant negative symptoms

Abstract:
Lecture discovers the topic of schizophrenia with predominant negative symptoms and its treatments, focusing on the dialogue between scientific data and routine clinical practice. Negative symptoms are described from the historical point of view and terms of clinical psychopathology, via the discussion on psychometric scales used for their assessments, revealed domains, dimensions and factors, as well as the typology (e.g., primary, secondary, persistent, prominent, predominant), which address us to the target-focused treatment approaches regarding specific manifestations of negative symptoms. Current findings on neurobiology, pathophysiology and clinical representation of negative symptoms have been reviewed in detail. The importance of (i) following modern clinical guidelines, (ii) evidence-based algorithms, (iii) augmentation strategies of combined antipsychotic pharmacotherapy, (iv) patients’ needs in psychosocial intervention, cognitive remediation, paying appropriate attention to all the issues of biopsychosocial context , in general, and, finally, (v) switching from the stratified, personalized, precise medicine approach to the individualized therapy of each single patient with schizophrenia, have been reported.